產品名稱：26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4) Antibody

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.

Target	26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 300-328 amino acids from the C-terminal region of human PSMD4.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P55036 (UniProt, ExPASy)
UniProt Secondary AC	D3DV16, Q5VWC5, Q9NS92
UniProt Entry Name	PSMD4_HUMAN
Gene Symbol	PSMD4
GeneID	5710
OMIM	601648
NCBI Accession	NP_002801.1 NM_002810.2
HGNC	9561
KEGG	hsa:5710
Ensembl	ENSG00000159352
String	9606.ENSP00000357879
Molecular Weight	Calculated MW: 40.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4)