產品名稱：26S Proteasome Regulatory Subunit 6A (PSMC3) Antibody

26S Proteasome Regulatory Subunit 6A (PSMC3) Antibody is a Mouse Monoclonal against 26S Proteasome Regulatory Subunit 6A (PSMC3). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

Target	26S Proteasome Regulatory Subunit 6A (PSMC3)
Clonality	Monoclonal
Reactivity	Human, Monkey, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Purified recombinant fragment of human PSMC3 (AA: 53-152) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P17980 (UniProt, ExPASy)
UniProt Secondary AC	B2R8V1, Q3B757, Q3B865, Q53HU5, Q6GPG8, Q6IBS1, Q96HD3
UniProt Entry Name	PRS6A_HUMAN
Gene Symbol	PSMC3
GeneID	5702
OMIM	186852
NCBI Accession	NM_002804
HGNC	9549
KEGG	hsa:5702
Ensembl	ENSG00000165916
String	9606.ENSP00000481029
Molecular Weight	49 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Regulatory Subunit 6A (PSMC3)