產品名稱：5'-AMP-Activated Protein Kinase Subunit Beta-1 (AMPK beta) Antibody

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosesynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

Target	5'-AMP-Activated Protein Kinase Subunit Beta-1 (AMPK beta)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 4-34 amino acids from the N-terminal region of human AMPK beta (PRKAB1).
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9Y478 (UniProt, ExPASy)
UniProt Secondary AC	Q9UBV0, Q9UE20, Q9UEX2, Q9Y6V8
UniProt Entry Name	AAKB1_HUMAN
String	9606.ENSP00000229328
Molecular Weight	Calculated MW: 30.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat PRKAB1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 5'-AMP-Activated Protein Kinase Subunit Beta-1 (AMPK beta)