產品名稱：ABL1 (pY245) Antibody

ABL1 (pY245) Antibody is a Rabbit Polyclonal antibody against ABL1 (pY245). The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocations results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

Target	ABL1 (pY245)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around Y245 of human ABL1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P00519 (UniProt, ExPASy)
UniProt Secondary AC	A3KFJ3, Q13869, Q13870, Q16133, Q17R61, Q45F09
UniProt Entry Name	ABL1_HUMAN
Gene Symbol	ABL1
GeneID	25
OMIM	189980
NCBI Accession	NP_005148.2
HGNC	76
KEGG	hsa:25
Ensembl	ENSG00000097007
String	9606.ENSP00000361423
Molecular Weight	Calculated MW: 123 kDa Observed MW: 124 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on ABL1 (pY245)