產品名稱：ATM (pS1981) Antibody

ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. ATM and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in the gene encoding ATM are associated with ataxia telangiectasia, an autosomal recessive disorder.

Target	ATM (pS1981)
Clonality	Polyclonal
Target Modification	Ser1981
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, IF/ICC, DB
Host	Rabbit
Recommended dilutions	IF/ICC: 1/10 - 1/50, DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1981 of human ATM.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13315 (UniProt, ExPASy)
UniProt Secondary AC	B2RNX5, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7
UniProt Entry Name	ATM_HUMAN
KEGG	hsa:472
String	9606.ENSP00000278616
Molecular Weight	Calculated MW: 351 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on ATM (pS1981)