產品名稱：ATM (pS1981) Antibody

ATM (pS1981) Antibody is a Rabbit Polyclonal antibody against ATM (pS1981). The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Target	ATM (pS1981)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around S1981 of human ATM.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13315 (UniProt, ExPASy)
UniProt Secondary AC	B2RNX5, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7
UniProt Entry Name	ATM_HUMAN
Gene Symbol	ATM
GeneID	472
NCBI Accession	NP_000042.3
KEGG	hsa:472
String	9606.ENSP00000278616
Molecular Weight	Calculated MW: 351 kDa Observed MW: 370 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on ATM (pS1981)