產品名稱：Alsin (ALS2) Antibody

ALS2 Antibody is a Rabbit Polyclonal antibody against ALS2. The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.

Target	Alsin (ALS2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 260-429 of human ALS2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q96Q42 (UniProt, ExPASy)
UniProt Secondary AC	Q53TT1, Q53TV2, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9
UniProt Entry Name	ALS2_HUMAN
Gene Symbol	ALS2
GeneID	57679
NCBI Accession	NP_065970.2
KEGG	hsa:57679
String	9606.ENSP00000264276
Molecular Weight	Calculated MW: 184 kDa Observed MW: 184 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Alsin (ALS2)