Anti-53BP1 antibody (1-100) [S8MR] (STJ11103538) STJ11103538|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-53BP1 antibody (1-100) [S8MR] (STJ11103538)
產品型號：STJ11103538
產品廠商：ST john's laboratory
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Anti-53BP1 antibody (1-100) [S8MR] (STJ11103538)

詳情介紹：

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-53BP1 (1-100) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	S8MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:100-1:500 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	TP53BP1
Gene ID:	7158
Uniprot ID:	TP53B_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human 53BP1 (Q12888).
Immunogen Sequence:	MDPTGSQLDSDFSQQDTPCL IIEDSQPESQVLEDDSGSHF SMLSRHLPNLQTHKENPVLD VVSNPEQTAGEERGDGNSGF NEHLKENKVADPVDSSNLDT

Post Translational Modifications	Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. Phosphorylated at basal level in the absence of DNA damage. Phosphorylated by ATM in response to DNA damage: phosphorylation at different sites promotes interaction with different set of proteins: phosphorylation at the N-terminus by ATM (residues from 6-178) promotes interaction with PAXIP1 and non-homologous end joining (NHEJ) of dysfunctional telomeres. Phosphorylation by ATM at residues that are located more C-terminus (residues 300-650) leads to promote interaction with RIF1. Interaction with RIF1 leads to disrupt interaction with NUDT16L1/TIRR. Phosphorylation at Thr-1609 and Ser-1618 in the UDR motif blocks interaction with H2AK15ub. Dephosphorylated by PPP4C. Hyperphosphorylation during mitosis correlates with its exclusion from chromatin and DNA lesions. Hyperphosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation. Dephosphorylated by PPP5C.
Function	Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites. Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites. Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs. Participates in the repair and the orientation of the broken DNA ends during CSR. In contrast, it is not required for classic NHEJ and V(D)J recombination. Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1.
Protein Name	Tp53-Binding Protein 1 53bp1 P53-Binding Protein 1 P53bp1
Database Links	Reactome: R-HSA-3232118 Reactome: R-HSA-5693565 Reactome: R-HSA-5693571 Reactome: R-HSA-5693607 Reactome: R-HSA-69473
Cellular Localisation	Nucleus Chromosome Centromere Kinetochore Localizes To The Nucleus In Absence Of Dna Damage Following Dna Damage Recruited To Sites Of Dna Damage Such As Double Stand Breaks (Dsbs): Recognizes And Binds Histone H2a Monoubiquitinated At 'Lys-15' (H2ak15ub) And Histone H4 Dimethylated At 'Lys-20' (H4k20me2) Two Histone Marks That Are Present At Dsbs Sites Associated With Kinetochores During Mitosis
Alternative Antibody Names	Anti-Tp53-Binding Protein 1 antibody Anti-53bp1 antibody Anti-P53-Binding Protein 1 antibody Anti-P53bp1 antibody Anti-TP53BP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-53BP1 antibody (1-100) [S8MR] (STJ11103538)