產品詳情
簡單介紹:
5HT1A Positive Control for STJ500002 peptide (STJ503612)
詳情介紹:
Applications: | WB |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | 5HT1A Positive Control for STJ500002 is synthetically produced from the sequence and is suitable for use in western blot applications. |
Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | Htr1a |
Gene ID: | 24473 |
Uniprot ID: | 5HT1A_RAT |
Specificity: | This is positive control is recommended for use in combination with 5HT1A antibody STJ500002. |
Immunogen: | Partially purified rat aquaporin 7 protein. |
Tissue Specificity | Detected in hypothalamus, mesencephalon, amygdala, medulla, thalamus, septum and hippocampus. |
Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. |
Peptide Name | 5-Hydroxytryptamine Receptor 1a 5-Ht-1a 5-Ht1a Serotonin Receptor 1a |
Database Links | Reactome: R-RNO-390666 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Cell Projection Dendrite |
Alternative Peptide Names | 5-Hydroxytryptamine Receptor 1a protein 5-Ht-1a protein 5-Ht1a protein Serotonin Receptor 1a protein Htr1a protein 5ht1a protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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