產品詳情
簡單介紹:
ADA Blocking Peptide for STJ506023 peptide (STJ505780)
詳情介紹:
Applications: | Immunodepletion/Immunocompetition |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | ADA Blocking Peptide for STJ506023 is synthetically produced from the 50-100 sequence and is suitable for use in western blot applications. |
Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | ADA |
Gene ID: | 100 |
Uniprot ID: | ADA_HUMAN |
Immunogen Region: | 50-100 |
Specificity: | This blocking peptide is recommended for use in combination with ADA antibody, STJ506023 |
Immunogen: | Synthetic peptide taken within amino acid region 50-100 on human Adenosine Deaminase/Adenosine Aminohydrolase. |
Tissue Specificity | Found in all tissues, occurs in large amounts in T-lymphocytes. Expressed at the time of weaning in gastrointestinal tissues. |
Function | Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion. Enhances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development. |
Peptide Name | Adenosine Deaminase Adenosine Aminohydrolase |
Database Links | Reactome: R-HSA-74217 Reactome: R-HSA-9734735 Reactome: R-HSA-9755088 |
Cellular Localisation | Cell Membrane Peripheral Membrane Protein Extracellular Side Cell Junction Cytoplasmic Vesicle Lumen Cytoplasm Lysosome Colocalized With Dpp4 At The Cell Surface |
Alternative Peptide Names | Adenosine Deaminase protein Adenosine Aminohydrolase protein ADA protein ADA1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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