產品詳情
簡單介紹:
Aquaporin 2 Positive Control for STJ502108 peptide (STJ503674)
詳情介紹:
Applications: | WB |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Aquaporin 2 Positive Control for STJ502108 is synthetically produced from the sequence and is suitable for use in western blot applications. |
Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
Dilution Range: | WB: 1:500 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | Aqp2 |
Gene ID: | 25386 |
Uniprot ID: | AQP2_RAT |
Specificity: | This is positive control is recommended for use in combination with Aquaporin 2 antibody STJ502108. |
Tissue Specificity | Detected in kidney, in cortical and the medullary collecting tubules (at protein level). Detected in kidney medulla and cortex. |
Post Translational Modifications | Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent. N-glycosylated. |
Function | Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. |
Peptide Name | Aquaporin-2 Aqp-2 Adh Water Channel Aquaporin-Cd Aqp-Cd Collecting Duct Water Channel Protein Wch-Cd Water Channel Protein For Renal Collecting Duct |
Database Links | Reactome: R-RNO-432040 Reactome: -RNO-432047 |
Cellular Localisation | Apical Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Cell Membrane Cytoplasmic Vesicle Membrane Golgi Apparatus Trans-Golgi Network Membrane Shuttles From Vesicles To The Apical Membrane Vasopressin-Regulated Phosphorylation Is Required For Translocations To The Apical Cell Membrane Plekha8/Fapp2 Is Required To Transport Aqp2 From The Tgn To Sites Where Aqp2 Is Phosphorylated |
Alternative Peptide Names | Aquaporin-2 protein Aqp-2 protein Adh Water Channel protein Aquaporin-Cd protein Aqp-Cd protein Collecting Duct Water Channel Protein protein Wch-Cd protein Water Channel Protein For Renal Collecting Duct protein Aqp2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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