Aquaporin 4 Blocking Peptide peptide (STJ503664) STJ503664-250|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Aquaporin 4 Blocking Peptide peptide (STJ503664)
產品型號：STJ503664-250
產品廠商：ST john's laboratory
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簡單介紹：

Aquaporin 4 Blocking Peptide peptide (STJ503664)

詳情介紹：

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Aquaporin 4 Blocking Peptide is synthetically produced from the 300-323 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	AQP4
Gene ID:	361
Uniprot ID:	AQP4_HUMAN
Immunogen Region:	300-323
Immunogen:	Synthetic peptide taken within amino acid region 300-323 on rat Aquaporin 4 protein.

Tissue Specificity	Detected in skeletal muscle. Detected in stomach, along the glandular base region of the fundic gland (at protein level). Detected in brain, lung and skeletal muscle, and at much lower levels in heart and ovary.
Post Translational Modifications	Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamate increases conductance by 40%. Isoform 2: Palmitoylated on its N-terminal region. Isoform 1: Not palmitoylated.
Function	Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability.
Peptide Name	Aquaporin-4 Aqp-4 Mercurial-Insensitive Water Channel Miwc Wch4
Database Links	Reactome: R-HSA-432040 Reactome: R-HSA-432047
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Endosome Membrane Sarcolemma Cell Projection Activation Of The Vasopressin Receptor Avpr1a Triggers Aqp4 Phosphorylation At Ser-180 And Promotes Its Internalization From The Cell Membrane Detected On Brain Astrocyte Processes And Astrocyte Endfeet Close To Capillaries
Alternative Peptide Names	Aquaporin-4 protein Aqp-4 protein Mercurial-Insensitive Water Channel protein Miwc protein Wch4 protein AQP4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Aquaporin 4 Blocking Peptide peptide (STJ503664)