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Anti-ABCB6 antibody (STJA0007484) STJA0007484|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司
產品詳情

  • 產品名稱：Anti-ABCB6 antibody (STJA0007484)

  • 產品型號：STJA0007484
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-ABCB6 antibody (STJA0007484)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ATP-binding cassette sub-family B member 6 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCB6
Gene ID: 10058
Uniprot ID: ABCB6_HUMAN
Specificity: This antibody detects endogenous levels of ABCB6 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human ABCB6
Post Translational Modifications N-glycosylated.
Function ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen. May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosesynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress. May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils. In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin. In addition may play a role in the transition metal homeostasis.
Protein Name Atp-Binding Cassette Sub-Family B Member 6
Abc-Type Heme Transporter Abcb6
Mitochondrial Abc Transporter 3
Mt-Abc Transporter 3
P-Glycoprotein-Related Protein
Ubiquitously-Expressed Mammalian Abc Half Transporter
Database Links Reactome: R-HSA-1369007
Reactome: R-HSA-5683371
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Mitochondrion Outer Membrane
Endoplasmic Reticulum Membrane
Golgi Apparatus Membrane
Endosome Membrane
Lysosome Membrane
Late Endosome Membrane
Early Endosome Membrane
Secreted
Extracellular Exosome
Mitochondrion
Endosome
Multivesicular Body Membrane
Melanosome Membrane
Present In The Membrane Of Mature Erythrocytes And In Exosomes Released From Reticulocytes During The Final Steps Of Erythroid Maturation
Traffics From Endoplasmic Reticulum To Golgi During Its Glycans's Maturation
Therefrom Is First Targeted To The Plasma Membrane
And Is Rapidly Internalized Through Endocytosis To Be Distributed To The Limiting Membrane Of Multivesicular Bodies And Lysosomes
Localized On The Limiting Membrane Of Early Melanosomes Of Pigment Cells
Targeted To The Endolysosomal Compartment
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family B Member 6 antibody
Anti-Abc-Type Heme Transporter Abcb6 antibody
Anti-Mitochondrial Abc Transporter 3 antibody
Anti-Mt-Abc Transporter 3 antibody
Anti-P-Glycoprotein-Related Protein antibody
Anti-Ubiquitously-Expressed Mammalian Abc Half Transporter antibody
Anti-ABCB6 antibody
Anti-MTABC3 antibody
Anti-PRP antibody
Anti-UMAT antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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