Human ACE-2 protein (Recombinant) (His-Tag) (STJP000682) STJP000682|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human ACE-2 protein (Recombinant) (His-Tag) (STJP000682)
產品型號：STJP000682
產品廠商：ST john's laboratory
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Human ACE-2 protein (Recombinant) (His-Tag) (STJP000682)

詳情介紹：

Host:	HEK293
Note:	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human ACE-2-His-Tag protein was developed from hek293 and has a target region of His-Tag. For use in research applications.

Conjugation:	Unconjugated
Formulation:	Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range:	Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction:	The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. NA
Endotoxin:	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA

Gene Symbol:	ACE2
Gene ID:	59272
Uniprot ID:	ACE2_HUMAN
Immunogen Region:	ECD
Immunogen:	DNA sequence encoding the extracellular domain of Human ACE2 including a C-terminal His tag was expressed in HEK293 Cells. NA
Immunogen Sequence:	QSTIEEQAKT FLDKFNHEAE DLFYQSSLAS WNYNTNITEE NVQNMNNAGD KWSAFLKEQS TLAQMYPLQE IQNLTVKLQL QALQQNGSSV LSEDKSKRLN TILNTMSTIY STGKVCNPDN PQECLLLEPG LNEIMANSLD YNERLWAWES WRSEVGKQLR PLYEEYVVLK NEMARANHYE DYGDYWRGDY EVNGVDGYDY SRGQLIEDVE HTFEEIKPLY EHLHAYVR

Tissue Specificity	Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells (at protein level). Expressed in enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in the renal proximal tubule and the small intestine (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system (at protein level). In lung, expressed at low levels in some alveolar type 2 cells, the expression seems to be individual-specific (at protein level). Expressed in nasal epithelial cells (at protein level). Coexpressed with TMPRSS2 within some lung alveolar type 2 cells, ileal absorptive enterocytes, intestinal epithelial cells, cornea, gallbladder and nasal goblet secretory cells. Coexpressed with TMPRSS4 within mature enterocytes. Isoform 2: Expressed in nasal and bronchial epithelial cells (at protein level).
Post Translational Modifications	N-glycosylation on Asn-90 may limit SARS infectivity. Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1. Phosphorylated. Phosphorylation at Tyr-781 probably inhibits interaction with AP2M1 and enables interactions with proteins containing SH2 domains.
Function	Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins (apelin-13, Pyr1apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency. In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity. (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. Isoform 2: Non-functional as a carboxypeptidase. Isoform 2: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2.
Protein Name	Angiotensin-Converting Enzyme 2 Angiotensin-Converting Enzyme Homolog Aceh Angiotensin-Converting Enzyme-Related Carboxypeptidase Ace-Related Carboxypeptidase Metalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2
Database Links	Reactome: R-HSA-2022377 Reactome: R-HSA-9678110 Reactome: R-HSA-9679191 Reactome: R-HSA-9694614 Reactome: R-HSA-9733458
Cellular Localisation	Processed Angiotensin-Converting Enzyme 2: Secreted Cell Membrane Single-Pass Type I Membrane Protein Cytoplasm Cell Projection Cilium Apical Cell Membrane Detected In Both Cell Membrane And Cytoplasm In Neurons Isoform 2: Apical Cell Membrane
Alternative Protein Names	Angiotensin-Converting Enzyme 2 protein Angiotensin-Converting Enzyme Homolog protein Aceh protein Angiotensin-Converting Enzyme-Related Carboxypeptidase protein Ace-Related Carboxypeptidase protein Metalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2 protein ACE2 protein UNQ868 protein PRO1885 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human ACE-2 protein (Recombinant) (His-Tag) (STJP000682)