Anti-ABCC6 antibody (830-940) (STJ110399) STJ110399|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-ABCC6 antibody (830-940) (STJ110399)
產品型號：STJ110399
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-ABCC6 antibody (830-940) (STJ110399)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ABCC6 (830-940) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABCC6
Gene ID:	368
Uniprot ID:	MRP6_HUMAN
Immunogen Region:	830-940
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 830-940 of human ABCC6 (NP_001162.4).
Immunogen Sequence:	AIAEMGSYQELLQRKGALVC LLDQARQPGDRGEGETEPGT STKDPRGTSAGRRPELRRER SIKSVPEKDRTTSEAQTEVP LDDPDRAGWPAGKDSIQYGR VKATVHLAYLR

Tissue Specificity	Expressed in kidney and liver. Very low expression in other tissues. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells and moderately in the adluminal compartment of the seminiferous tubules.
Post Translational Modifications	Glycosylated.
Function	Isoform 1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin. Isoform 1: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.
Protein Name	Atp-Binding Cassette Sub-Family C Member 6 Anthracycline Resistance-Associated Protein Multi-Specific Organic Anion Transporter E Moat-E Multidrug Resistance-Associated Protein 6
Database Links	Reactome: R-HSA-382556 Reactome: R-HSA-5690338
Cellular Localisation	Basal Cell Membrane Multi-Pass Membrane Protein Localized To The Basal Membrane Of Sertoli Cells Isoform 1: Basolateral Cell Membrane Isoform 2: Endoplasmic Reticulum Membrane Single-Pass Membrane Protein
Alternative Antibody Names	Anti-Atp-Binding Cassette Sub-Family C Member 6 antibody Anti-Anthracycline Resistance-Associated Protein antibody Anti-Multi-Specific Organic Anion Transporter E antibody Anti-Moat-E antibody Anti-Multidrug Resistance-Associated Protein 6 antibody Anti-ABCC6 antibody Anti-ARA antibody Anti-MRP6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ABCC6 antibody (830-940) (STJ110399)