Anti-ABCE1 antibody (320-599) (STJ110445) STJ110445|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-ABCE1 antibody (320-599) (STJ110445)
產品型號：STJ110445
產品廠商：ST john's laboratory
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Anti-ABCE1 antibody (320-599) (STJ110445)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ABCE1 (320-599) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABCE1
Gene ID:	6059
Uniprot ID:	ABCE1_HUMAN
Immunogen Region:	320-599
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 320-599 of human ABCE1 (NP_002931.2).
Immunogen Sequence:	ENLRFRDASLVFKVAETANE EEVKKMCMYKYPGMKKKMGE FELAIVAGEFTDSEIMVMLG ENGTGKTTFIRMLAGRLKPD EGGEVPVLNVSYKPQKISPK STGSVRQLLHEKIRDAYTHP QFVTDVMKPLQIENIIDQEV QTLSGGELQRVALALCLGKP ADVYLIDEPSAYLDSEQRLM AARVVKRFILHAKKTAFVVE HDFIMATYLADRVIVFDGVP SKNTVANSPQTLLAGMNKF

Post Translational Modifications	Ubiquitinated by CNOT4. Ubiquitination mediates the recruitment of autophagy receptors to the mitochondrial outer membrane and initiates mitophagy.
Function	Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly. Able to hydrolyze ATP, GTP, UTP and CTP. Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits. Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage.this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL. Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway. (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections.
Protein Name	Atp-Binding Cassette Sub-Family E Member 1 2'-5'-Oligoadenylate-Binding Protein Huhp68 Rnase L Inhibitor Ribonuclease 4 Inhibitor Rns4i
Database Links	Reactome: R-HSA-8983711 Reactome: R-HSA-909733
Cellular Localisation	Cytoplasm Mitochondrion
Alternative Antibody Names	Anti-Atp-Binding Cassette Sub-Family E Member 1 antibody Anti-2'-5'-Oligoadenylate-Binding Protein antibody Anti-Huhp68 antibody Anti-Rnase L Inhibitor antibody Anti-Ribonuclease 4 Inhibitor antibody Anti-Rns4i antibody Anti-ABCE1 antibody Anti-RLI antibody Anti-RNASEL1 antibody Anti-RNASELI antibody Anti-RNS4I antibody Anti-OK antibody Anti-SW-cl.40 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ABCE1 antibody (320-599) (STJ110445)