Human AGER/RAGE protein (Recombinant) (C-hFc & His) (STJP002587) STJP002587|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human AGER/RAGE protein (Recombinant) (C-hFc & His) (STJP002587)
產品型號：STJP002587
產品廠商：ST john's laboratory
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Human AGER/RAGE protein (Recombinant) (C-hFc & His) (STJP002587)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human AGER/RAGE-C-hFc & His protein was developed from hek293 cells and has a target region of C-hFc & His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	1.Measured by its binding ability in a functional ELISA. Immobilized Recombinant human HMGB1 at 2 Mu g/mL (100 Mu L/well) can bind Recombinant human AGER with a linear range of 15-50 ng/mL.2.Measured by its binding ability in a functional ELISA. Immo

Gene Symbol:	AGER
Gene ID:	177
Uniprot ID:	RAGE_HUMAN
Immunogen Region:	Gln24-Ala344
Immunogen:	Recombinant Human AGER/RAGE Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln24-Ala344) of human AGER/RAGE (Accession #NP_001127.1) fused with an Fc, 6×His tag at the C-terminus.

Post Translational Modifications	Phosphorylated on its cytoplasmic domain by PKCzeta/PRKCZ upon ligand binding. Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation.
Function	Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans. Advanced glycosylation end products are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. These ligands accumulate at inflammatory sites during the pathogenesis of various diseases, including diabetes, vascular complications, neurodegenerative disorders, and cancers and RAGE transduces their binding into pro-inflammatory responses. Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction or inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Contributes to the translocations of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability. Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome. Promotes also extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses.
Protein Name	Advanced Glycosylation End Product-Specific Receptor Receptor For Advanced Glycosylation End Products
Database Links	Reactome: R-HSA-445989 Reactome: R-HSA-879415 Reactome: R-HSA-933542
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted Isoform 10: Cell Membrane
Alternative Protein Names	Advanced Glycosylation End Product-Specific Receptor protein Receptor For Advanced Glycosylation End Products protein AGER protein RAGE protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human AGER/RAGE protein (Recombinant) (C-hFc &amp; His) (STJP002587)

產品名稱：Human AGER/RAGE protein (Recombinant) (C-hFc & His) (STJP002587)