Human AMH protein (Recombinant) (N-His) (STJP002492) STJP002492-50|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Human AMH protein (Recombinant) (N-His) (STJP002492)

詳情介紹：

Host:	HEK293 Cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human AMH-N-His protein was developed from hek293 cells and has a target region of N-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	AMH
Gene ID:	268
Uniprot ID:	MIS_HUMAN
Immunogen Region:	Leu25-Arg560
Immunogen:	Recombinant Human AMH Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Leu25-Arg560) of AMH Protein (Accession #NP_000470.2) fused with 6×His tag at the N-terminus

Post Translational Modifications	Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHR2 induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus.
Function	Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation. Also plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.
Protein Name	Muellerian-Inhibiting Factor Anti-Muellerian Hormone Amh Muellerian-Inhibiting Substance Mis
Database Links	Reactome: R-HSA-201451 Reactome: R-HSA-9690406
Cellular Localisation	Secreted
Alternative Protein Names	Muellerian-Inhibiting Factor protein Anti-Muellerian Hormone protein Amh protein Muellerian-Inhibiting Substance protein Mis protein AMH protein MIF protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human AMH protein (Recombinant) (N-His) (STJP002492)