Human APLP-1 protein (Recombinant) (C-His) (STJP001344) STJP001344|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Human APLP-1 protein (Recombinant) (C-His) (STJP001344)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human APLP-1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:

Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.

Gene Symbol:	APLP1
Gene ID:	333
Uniprot ID:	APLP1_HUMAN
Immunogen:	Recombinant Human APLP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser39-Glu580) of human APLP1 (Accession #NP_005157.1) fused with a 6×His tag at the C-terminus.

Post Translational Modifications	Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3. N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228.
Function	May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
Protein Name	Amyloid Beta Precursor Like Protein 1 Amyloid Beta A4 Precursor-Like Protein 1 Amyloid-Like Protein 1 Aplp Aplp-1 Cleaved Into - C30
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein C30: Cytoplasm C-Terminally Processed In The Golgi Complex
Alternative Protein Names	Amyloid Beta Precursor Like Protein 1 protein Amyloid Beta protein A4 Precursor-Like Protein 1 protein Amyloid-Like Protein 1 protein Aplp protein Aplp-1 Cleaved Into - C30 protein APLP1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human APLP-1 protein (Recombinant) (C-His) (STJP001344)