Human Arginase 1/ARG1 protein (Recombinant) (C-His) (STJP001020) STJP001020|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human Arginase 1/ARG1 protein (Recombinant) (C-His) (STJP001020)
產品型號：STJP001020
產品廠商：ST john's laboratory
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Human Arginase 1/ARG1 protein (Recombinant) (C-His) (STJP001020)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human Arginase 1/ARG1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity:	Measured by the production of urea during the hydrolysis of arginine. The specific activity is >27833 pmol/min/Mu g.

Gene Symbol:	ARG1
Gene ID:	383
Uniprot ID:	ARGI1_HUMAN
Immunogen:	Recombinant Human Arginase 1/ARG1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Met 1-Lys 322 ) of human Arginase (Accession #NP_000036.2) fused with a 6×His tag at the C-terminus.

Tissue Specificity	Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes PMNs). Also detected in macrophages mycobacterial granulomas. Expressed in group2 innate lymphoid cells (ILC2s) during lung disease.
Function	Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively.the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion. In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival. In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure.
Protein Name	Arginase-1 Liver-Type Arginase Type I Arginase
Database Links	Reactome: R-HSA-6798695 Reactome: R-HSA-70635
Cellular Localisation	Cytoplasm Cytoplasmic Granule Localized In Azurophil Granules Of Neutrophils
Alternative Protein Names	Arginase-1 protein Liver-Type Arginase protein Type I Arginase protein ARG1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human Arginase 1/ARG1 protein (Recombinant) (C-His) (STJP001020)