Human AXL protein (Recombinant) (C-His-Avi) {Biotin} (STJP001761) STJP001761|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human AXL protein (Recombinant) (C-His-Avi) {Biotin} (STJP001761)
產品型號：STJP001761
產品廠商：ST john's laboratory
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Human AXL protein (Recombinant) (C-His-Avi) {Biotin} (STJP001761)

詳情介紹：

Host:	HEK293
Note:	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human AXL-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.

Conjugation:	Biotin
Formulation:	Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range:	Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction:	The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin:	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).

Gene Symbol:	AXL
Gene ID:	558
Uniprot ID:	UFO_HUMAN
Immunogen Region:	Ala26-Pro449
Immunogen:	DNA sequence encoding Human AXL including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.

Post Translational Modifications	Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion. Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3.but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes. Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection. Interferon signaling inhibition occurs via an SOCS1-dependent mechanism.
Protein Name	Tyrosine-Protein Kinase Receptor Ufo Axl Oncogene
Database Links	Reactome: R-HSA-4420097
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Tyrosine-Protein Kinase Receptor Ufo protein Axl Oncogene protein AXL protein UFO protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human AXL protein (Recombinant) (C-His-Avi) {Biotin} (STJP001761)