BACE2 A/C Blocking Peptide peptide (STJ503692) STJ503692-250|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：BACE2 A/C Blocking Peptide peptide (STJ503692)
產品型號：STJ503692-250
產品廠商：ST john's laboratory
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簡單介紹：

BACE2 A/C Blocking Peptide peptide (STJ503692)

詳情介紹：

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	BACE2 A/C Blocking Peptide is synthetically produced from the 490-518 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	BACE2
Gene ID:	25825
Uniprot ID:	BACE2_HUMAN
Immunogen Region:	490-518
Immunogen:	Synthetic peptide taken within amino acid region 490-518 on human BACE2 protein.

Tissue Specificity	Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
Post Translational Modifications	Undergoes autoproteolytic cleavage. Glycosylated.
Function	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
Peptide Name	Beta-Secretase 2 Aspartic-Like Protease 56 Kda Aspartyl Protease 1 Asp1 Asp 1 Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 Beta-Site App Cleaving Enzyme 2 Down Region Aspartic Protease Drap Memapsin-1 Membrane-Associated Aspartic Protease 1 Theta-Secretase
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Golgi Apparatus Endoplasmic Reticulum Endosome Melanosome Colocalizes With Pmel In Stage I And Ii Melanosomes
Alternative Peptide Names	Beta-Secretase 2 protein Aspartic-Like Protease 56 Kda protein Aspartyl Protease 1 protein Asp1 protein Asp 1 protein Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 protein Beta-Site App Cleaving Enzyme 2 protein Down Region Aspartic Protease protein Drap protein Memapsin-1 protein Membrane-Associated Aspartic Protease 1 protein Theta-Secretase protein BACE2 protein AEPLC protein ALP56 protein ASP21 protein CDA13 protein UNQ418 protein PRO852 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：BACE2 A/C Blocking Peptide peptide (STJ503692)