BLK Positive Control for STJ500258 peptide (STJ505672) STJ505672-5|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：BLK Positive Control for STJ500258 peptide (STJ505672)
產品型號：STJ505672-5
產品廠商：ST john's laboratory
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BLK Positive Control for STJ500258 peptide (STJ505672)

詳情介紹：

Applications:	WB
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	BLK Positive Control for STJ500258 is synthetically produced from the sequence and is suitable for use in western blot applications.

Formulation:	Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range:	WB: 1:2, 500-1:5, 000
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	BLK
Gene ID:	640
Uniprot ID:	BLK_HUMAN
Specificity:	This is positive control is recommended for use in combination with BLK antibody STJ500258.
Immunogen:	Purified BLK protein.

Post Translational Modifications	Phosphorylated on tyrosine residues after antibody-mediated surface engagement of the B-cell antigen receptor (BCR). Ubiquitination of activated BLK by the UBE3A ubiquitin protein ligase leads to its degradation by the ubiquitin-proteasome pathway.
Function	Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose. Phosphorylates CGAS, promoting retention of CGAS in the cytosol.
Peptide Name	Tyrosine-Protein Kinase Blk B Lymphocyte Kinase P55-Blk
Database Links	Reactome: R-HSA-8939245 Reactome: R-HSA-983695
Cellular Localisation	Cell Membrane Lipid-Anchor Present And Active In Lipid Rafts Membrane locations Is Required For The Phosphorylation Of Cd79a And Cd79b
Alternative Peptide Names	Tyrosine-Protein Kinase Blk protein B Lymphocyte Kinase protein P55-Blk protein BLK protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：BLK Positive Control for STJ500258 peptide (STJ505672)