Anti-ABCG2 antibody (461-510 aa) (STJ97253) STJ97253|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

所在位置: 首頁> 產品目錄> S類> ST john's laboratory>

查看大圖

產品名稱：Anti-ABCG2 antibody (461-510 aa) (STJ97253)
產品型號：STJ97253
產品廠商：ST john's laboratory
產品文檔：

你添加了1件商品查看購物車

簡單介紹：

Anti-ABCG2 antibody (461-510 aa) (STJ97253)

詳情介紹：

Host:	Rabbit
Applications:	IF/WB/IHC/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Broad substrate specificity ATP-binding cassette transporter ABCG2 (461-510 aa) is suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IF 1:50-200 WB 1:500-1:2000 IHC-P 1:100-1:300 ELISA 1:10000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABCG2
Gene ID:	9429
Uniprot ID:	ABCG2_HUMAN
Immunogen Region:	461-510 aa
Specificity:	ABCG2 Polyclonal Antibody detects endogenous levels of ABCG2 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the Internal region of human ABCG2 at the amino acid range 461-510

Post Translational Modifications	N-glycosylated. Glycosylation-deficient ABCG2 is normally expressed and functional. Phosphorylated. Phosphorylation at Thr-362 by PIM1 is induced by drugs like mitoxantrone and is associated with cells increased drug resistance. It regulates the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter.
Function	Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion. In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate. Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates. Mediates the secretion of the riboflavin and biotin vitamins into milk. Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability. Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux. In placenta, it limits the penetration of drugs from the maternal plasma into the fetus. May play a role in early stem cell self-renewal by blocking differentiation.
Protein Name	Broad Substrate Specificity Atp-Binding Cassette Transporter Abcg2 Atp-Binding Cassette Sub-Family G Member 2 Breast Cancer Resistance Protein Cdw338 Mitoxantrone Resistance-Associated Protein Placenta-Specific Atp-Binding Cassette Transporter Urate Exporter Cd Antigen Cd338
Database Links	Reactome: R-HSA-189451 Reactome: R-HSA-189483 Reactome: R-HSA-2161517 Reactome: R-HSA-917937 Reactome: R-HSA-9753281 Reactome: R-HSA-9793528
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane Mitochondrion Membrane Enriched In Membrane Lipid Rafts
Alternative Antibody Names	Anti-Broad Substrate Specificity Atp-Binding Cassette Transporter Abcg2 antibody Anti-Atp-Binding Cassette Sub-Family G Member 2 antibody Anti-Breast Cancer Resistance Protein antibody Anti-Cdw338 antibody Anti-Mitoxantrone Resistance-Associated Protein antibody Anti-Placenta-Specific Atp-Binding Cassette Transporter antibody Anti-Urate Exporter antibody Anti-Cd Antigen Cd338 antibody Anti-ABCG2 antibody Anti-ABCP antibody Anti-BCRP antibody Anti-BCRP1 antibody Anti-MXR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

姓名：

電話：

您的需求：

產品名稱：Anti-ABCG2 antibody (461-510 aa) (STJ97253)