Human B7-2/CD86 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001765) STJP001765|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human B7-2/CD86 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001765)
產品型號：STJP001765
產品廠商：ST john's laboratory
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Human B7-2/CD86 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001765)

詳情介紹：

Host:	HEK293
Note:	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human B7-2/CD86-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.

Conjugation:	Biotin
Formulation:	Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range:	Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction:	The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin:	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).

Gene Symbol:	CD86
Gene ID:	942
Uniprot ID:	CD86_HUMAN
Immunogen Region:	Leu26-Pro247
Immunogen:	DNA sequence encoding Human B7-2/CD86 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then test biotinylated site specific using the AVItag biotinylation technology.test NA

Post Translational Modifications	Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Function	Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. Isoform 2: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.
Protein Name	T-Lymphocyte Activation Antigen Cd86 Activation B7-2 Antigen B70 Bu63 Ctla-4 Counter-Receptor B7.2 Fun-1 Cd Antigen Cd86
Database Links	Reactome: R-HSA-1257604 Reactome: R-HSA-2219530 Reactome: R-HSA-389356 Reactome: R-HSA-389357 Reactome: R-HSA-389359 Reactome: R-HSA-389513 Reactome: R-HSA-6783783 Reactome: R-HSA-6811558
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	T-Lymphocyte Activation Antigen Cd86 protein Activation B7-2 Antigen protein B70 protein Bu63 protein Ctla-4 Counter-Receptor B7.2 protein Fun-1 protein Cd Antigen Cd86 protein CD86 protein CD28LG2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human B7-2/CD86 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001765)