Human BACE-1/ASP2 protein (Recombinant) (C-His) (STJP000940) STJP000940|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human BACE-1/ASP2 protein (Recombinant) (C-His) (STJP000940)
產品型號：STJP000940
產品廠商：ST john's laboratory
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簡單介紹：

Human BACE-1/ASP2 protein (Recombinant) (C-His) (STJP000940)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human BACE-1/ASP2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity:	Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK (Dpn) RR-NH2. The specific activity is >5.5 pmol/min/Mu g.

Gene Symbol:	BACE1
Gene ID:	23621
Uniprot ID:	BACE1_HUMAN
Immunogen:	Recombinant Human BACE-1/ASP2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Thr22-Tyr460) of human BACE1/ASP2 (Accession #NP_036236.1) fused with an 8×His tag at the C-terminus.

Tissue Specificity	Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
Post Translational Modifications	N-Glycosylated. Addition of a bisecting N-acetylglucosamine by MGAT3 blocks lysosomal targeting, further degradation and is required for maintaining stability under stress conditions. Acetylated in the endoplasmic reticulum at Lys-126, Lys-275, Lys-279, Lys-285, Lys-299, Lys-300 and Lys-307. Acetylation by NAT8 and NAT8B is transient and deacetylation probably occurs in the Golgi. Acetylation regulates the maturation, the transport to the plasma membrane, the stability and the expression of the protein. Palmitoylation mediates lipid raft localization. Ubiquitinated at Lys-501, ubiquitination leads to lysosomal degradation. Monoubiquitinated and 'Lys-63'-linked polyubitinated. Deubiquitnated by USP8.inhibits lysosomal degradation. Phosphorylation at Ser-498 is required for interaction with GGA1 and retrograded transport from endosomal compartments to the trans-Golgi network. Non-phosphorylated BACE1 enters a direct recycling route to the cell surface.
Function	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves CHL1.
Protein Name	Beta-Secretase 1 Aspartyl Protease 2 Asp2 Asp 2 Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Beta-Site App Cleaving Enzyme 1 Memapsin-2 Membrane-Associated Aspartic Protease 2
Database Links	Reactome: R-HSA-977225
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Golgi Apparatus Trans-Golgi Network Endoplasmic Reticulum Endosome Cell Surface Cytoplasmic Vesicle Membrane Membrane Raft Lysosome Late Endosome Early Endosome Recycling Endosome Cell Projection Axon Dendrite Predominantly Localized To The Later Golgi/Trans-Golgi Network (Tgn) And Minimally Detectable In The Early Golgi Compartments A Small Portion Is Also Found In The Endoplasmic Reticulum Endosomes And On The Cell Surface Colocalization With App In Early Endosomes Is Due To Addition Of Bisecting N-Acetylglucosamine Wich Blocks Targeting To Late Endosomes And Lysosomes Retrogradly Transported From Endosomal Compartments To The Trans-Golgi Network In A Phosphorylation- And Gga1- Dependent Manner
Alternative Protein Names	Beta-Secretase 1 protein Aspartyl Protease 2 protein Asp2 protein Asp 2 protein Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 protein Beta-Site App Cleaving Enzyme 1 protein Memapsin-2 protein Membrane-Associated Aspartic Protease 2 protein BACE1 protein BACE protein KIAA1149 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human BACE-1/ASP2 protein (Recombinant) (C-His) (STJP000940)