Human BID protein (Recombinant) (C-His) (STJP000795) STJP000795|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human BID protein (Recombinant) (C-His) (STJP000795)
產品型號：STJP000795
產品廠商：ST john's laboratory
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簡單介紹：

Human BID protein (Recombinant) (C-His) (STJP000795)

詳情介紹：

Host:	E. coli
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human BID-C-His protein was developed from e. coli and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of 50mM TRIS, 150mM NaCl, pH 8.0. Contact us for customized product form or formulation.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human BID at 2 Mu g/mL (100 Mu L/well) can bind BCL-XL with a linear range of 0.195-4.94 ng/mL.

Gene Symbol:	BID
Gene ID:	637
Uniprot ID:	BID_HUMAN
Immunogen Region:	Met1-Asp195
Immunogen:	Recombinant Human BID Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Asp195) of human BID (Accession #NP_001187.1) fused with a 6×His tag at the C-terminus.

Tissue Specificity	Isoform 2: Expressed in spleen, pancreas and placenta (at protein level). Isoform 3: Expressed in lung, pancreas and spleen (at protein level). Isoform 4: Expressed in lung and pancreas (at protein level).
Post Translational Modifications	BH3-interacting domain death agonist: TNF-alpha induces caspase-mediated cleavage into a major p15 and minor p13 and p11 products. Cleaved by CASP6 into a major p15 and minor p13 products, leading to release of cytochrome c and subsequent nonalcoholic steatohepatitis. BH3-interacting domain death agonist p15: Ubiquitinated by ITCH.ubiquitination results in proteasome-dependent degradation.
Function	Induces caspases and apoptosis. Counters the protective effect of BCL2. BH3-interacting domain death agonist p15: Induces caspase activation and apoptosis. Allows the release of cytochrome c. Isoform 1: Induces ICE-like proteases and apoptosis. Isoform 2: Induces ICE-like proteases and apoptosis. Isoform 3: Does not induce apoptosis. Isoform 4: Induces ICE-like proteases and apoptosis.
Protein Name	Bh3-Interacting Domain Death Agonist P22 Bid Bid Cleaved Into - Bh3-Interacting Domain Death Agonist P15 P15 Bid - Bh3-Interacting Domain Death Agonist P13 P13 Bid - Bh3-Interacting Domain Death Agonist P11 P11 Bid
Database Links	Reactome: R-HSA-111447 Reactome: R-HSA-111452 Reactome: R-HSA-111453 Reactome: R-HSA-114294 Reactome: R-HSA-6803204 Reactome: R-HSA-75108
Cellular Localisation	Cytoplasm Mitochondrion Membrane Mitochondrion Outer Membrane When Uncleaved It Is Predominantly Cytoplasmic Bh3-Interacting Domain Death Agonist P15: Mitochondrion Membrane Translocates To Mitochondria As An Integral Membrane Protein Bh3-Interacting Domain Death Agonist P13: Mitochondrion Membrane Associated With The Mitochondrial Membrane Isoform 1: Cytoplasm Isoform 3: Cytoplasm Isoform 2: Mitochondrion Membrane A Significant Proportion Of Isoform 2 Localizes To Mitochondria It May Be Cleaved Constitutively
Alternative Protein Names	Bh3-Interacting Domain Death Agonist protein P22 Bid protein Bid Cleaved Into - Bh3-Interacting Domain Death Agonist P15 protein P15 Bid - Bh3-Interacting Domain Death Agonist P13 protein P13 Bid - Bh3-Interacting Domain Death Agonist P11 protein P11 Bid protein BID protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human BID protein (Recombinant) (C-His) (STJP000795)