BMP2 Positive Control for STJ500274 peptide (STJ503746) STJ503746-5|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：BMP2 Positive Control for STJ500274 peptide (STJ503746)
產品型號：STJ503746-5
產品廠商：ST john's laboratory
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BMP2 Positive Control for STJ500274 peptide (STJ503746)

詳情介紹：

Applications:	WB
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	BMP2 Positive Control for STJ500274 is synthetically produced from the sequence and is suitable for use in western blot applications.

Formulation:	Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range:	WB: 1:500-1:, 1000
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Bmp2
Gene ID:	12156
Uniprot ID:	BMP2_MOUSE
Specificity:	This is positive control is recommended for use in combination with BMP2 antibody STJ500274.

Function	Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling.
Peptide Name	Bone Morphogenetic Protein 2 Bmp-2 Bone Morphogenetic Protein 2a Bmp-2a
Database Links	Reactome: R-MMU-201451 Reactome: -MMU-2129379
Cellular Localisation	Secreted
Alternative Peptide Names	Bone Morphogenetic Protein 2 protein Bmp-2 protein Bone Morphogenetic Protein 2a protein Bmp-2a protein Bmp2 protein Bmp-2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：BMP2 Positive Control for STJ500274 peptide (STJ503746)