BST2 Blocking Peptide for STJ500294 peptide (STJ503733) STJ503733-250|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：BST2 Blocking Peptide for STJ500294 peptide (STJ503733)
產品型號：STJ503733-250
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

BST2 Blocking Peptide for STJ500294 peptide (STJ503733)

詳情介紹：

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	BST2 Blocking Peptide for STJ500294 is synthetically produced from the 50-100 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	BST2
Gene ID:	684
Uniprot ID:	BST2_HUMAN
Immunogen Region:	50-100
Specificity:	This blocking peptide is recommended for use in combination with BST2 antibody, STJ500294
Immunogen:	Mid-Region Epitope Synthetic peptide taken within amino acid region 50-100 on human Bonemarrow stromal antigen 2 protein.

Tissue Specificity	Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level).
Post Translational Modifications	Monoubiquitinated by KSHV E3 ubiquitin-protein ligase K5, leading to its targeting to late endosomes and degradation. The GPI anchor is essential for its antiviral activity.
Function	IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, paramyxoviridae: nipah virus, and coronaviridae: SARS-CoV. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities. Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu. Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2.
Peptide Name	Bone Marrow Stromal Antigen 2 Bst-2 Hm1.24 Antigen Tetherin Cd Antigen Cd317
Database Links	Reactome: R-HSA-6798695 Reactome: R-HSA-909733 Reactome: R-HSA-9692916
Cellular Localisation	Golgi Apparatus Trans-Golgi Network Cell Membrane Single-Pass Type Ii Membrane Protein Lipid-Anchor Gpi-Anchor Membrane Raft Cytoplasm Apical Cell Membrane Shuttles Between The Cell Membrane Where It Is Present Predominantly In Membrane/Lipid Rafts And The Trans-Golgi Network Forms A Complex With Mmp14 And Localizes To The Cytoplasm Late Endosome (Microbial Infection) Hiv-1 Vpu And Hiv-2 Env Can Target It To The Trans-Golgi Network Thus Sequestering It Away From Virus Assembly Sites On The Cell Membrane Targeted To Late Endosomes Upon Kshv Infection And Subsequent Ubiquitination
Alternative Peptide Names	Bone Marrow Stromal Antigen 2 protein Bst-2 protein Hm1.24 Antigen protein Tetherin protein Cd Antigen Cd317 protein BST2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：BST2 Blocking Peptide for STJ500294 peptide (STJ503733)