Anti-ABL2 antibody (1100-1150) {Biotin} (STJ506089) STJ506089-100|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-ABL2 antibody (1100-1150) {Biotin} (STJ506089)
產品型號：STJ506089-100
產品廠商：ST john's laboratory
產品文檔：

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Anti-ABL2 antibody (1100-1150) {Biotin} (STJ506089)

詳情介紹：

Host:	Rabbit
Applications:	ELISA/IP/WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ABL2 (1100-1150) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.5-1.5 µg/µl
Dilution Range:	WB: 1:500-1:5, 000 ELISA: 1:50, 000 IP: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	ABL2
Gene ID:	27
Uniprot ID:	ABL2_HUMAN
Immunogen Region:	1100-1150
Immunogen:	Synthetic peptide corresponding to amino acids within region 1100-1150 on human Tyrosine-protein kinase ABL2/ARG.

Tissue Specificity	Widely expressed.
Post Translational Modifications	Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB. Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.
Function	Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement).CTTN (involved in signaling).or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1.
Protein Name	Tyrosine-Protein Kinase Abl2 Abelson Murine Leukemia Viral Oncogene Homolog 2 Abelson Tyrosine-Protein Kinase 2 Abelson-Related Gene Protein Tyrosine-Protein Kinase Arg
Database Links	Reactome: R-HSA-428890 Reactome: R-HSA-9013149 Reactome: R-HSA-9013423 Reactome: R-HSA-9706369
Cellular Localisation	Cytoplasm Cytoskeleton
Alternative Antibody Names	Anti-Tyrosine-Protein Kinase Abl2 antibody Anti-Abelson Murine Leukemia Viral Oncogene Homolog 2 antibody Anti-Abelson Tyrosine-Protein Kinase 2 antibody Anti-Abelson-Related Gene Protein antibody Anti-Tyrosine-Protein Kinase Arg antibody Anti-ABL2 antibody Anti-ABLL antibody Anti-ARG antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ABL2 antibody (1100-1150) {Biotin} (STJ506089)