Human c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP002574) STJP002574|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Human c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP002574)
產品型號：STJP002574
產品廠商：ST john's laboratory
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Human c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP002574)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human c-Kit ligand/SCF/KITLG-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	1.Measured in a cell proliferation assay using TF-1 Human erythroleukemic cells. The ED50 for this effect is 0.08-0.3 ng/mL.2.Measured by its binding ability in a functional ELISA. Immobilized recombinant human SCF at 1 Mu g/mL (100 Mu L/well) can bi

Gene Symbol:	KITLG
Gene ID:	4254
Uniprot ID:	SCF_HUMAN
Immunogen Region:	Glu26-His214
Immunogen:	Recombinant Human c-Kit ligand/SCF/KITLG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu26-His214) of human SCF/C-kit ligand (Accession #NP_000890.1) fused with a 6×His tag at the C-terminus.

Function	Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Protein Name	Kit Ligand Mast Cell Growth Factor Mgf Stem Cell Factor Scf C-Kit Ligand Cleaved Into - Soluble Kit Ligand Skitlg
Database Links	Reactome: R-HSA-1257604 P21583-1 Reactome: R-HSA-1433557 P21583-1 Reactome: R-HSA-1433559 P21583-1 Reactome: R-HSA-2219530 P21583-1 Reactome: R-HSA-5673001 P21583-1 Reactome: R-HSA-6811558 P21583-1
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Cytoplasm Cytoplasm Cytoskeleton Cell Membrane Cell Projection Lamellipodsium Filopodium Soluble Kit Ligand: Secreted
Alternative Protein Names	Kit Ligand protein Mast Cell Growth Factor protein Mgf protein Stem Cell Factor protein Scf protein C-Kit Ligand Cleaved Into - Soluble Kit Ligand protein Skitlg protein KITLG protein MGF protein SCF protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP002574)