Human c-Kit/CD117 protein (Recombinant) (C-hFc & His) (STJP002568) STJP002568|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

所在位置: 首頁> 產品目錄> S類> ST john's laboratory>

查看大圖

產品名稱：Human c-Kit/CD117 protein (Recombinant) (C-hFc & His) (STJP002568)
產品型號：STJP002568
產品廠商：ST john's laboratory
產品文檔：

你添加了1件商品查看購物車

簡單介紹：

Human c-Kit/CD117 protein (Recombinant) (C-hFc & His) (STJP002568)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human c-Kit/CD117-C-hFc & His protein was developed from hek293 cells and has a target region of C-hFc & His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	1.Measured by its binding ability in a functional ELISA. Immobilized recombinant human SCF at 1 Mu g/mL (100 Mu L/well) can bind recombinant human CD117 with a linear range of 1-6 ng/mL.2.Measured by its binding ability in a functional ELISA. Immobil

Gene Symbol:	KIT
Gene ID:	3815
Uniprot ID:	KIT_HUMAN
Immunogen Region:	Gln26-Thr520
Immunogen:	Recombinant Human c-Kit/CD117 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln26-Thr520) of human KIT/c-KIT/CD117 (Accession #NP_000213.1) fused with an Fc, 6×His tag at the C-terminus.

Post Translational Modifications	Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation. Autophosphorylated on tyrosine residues. KITLG/SCF binding enhances autophosphorylation. Isoform 1 shows low levels of tyrosine phosphorylation in the absence of added KITLG/SCF (in vitro). Kinase activity is down-regulated by phosphorylation on serine residues by protein kinase C family members. Phosphorylation at Tyr-568 is required for interaction with PTPN11/SHP-2, CRK (isoform Crk-II) and members of the SRC tyrosine-protein kinase family. Phosphorylation at Tyr-570 is required for interaction with PTPN6/SHP-1. Phosphorylation at Tyr-703, Tyr-823 and Tyr-936 is important for interaction with GRB2. Phosphorylation at Tyr-721 is important for interaction with PIK3R1. Phosphorylation at Tyr-823 and Tyr-936 is important for interaction with GRB7.
Function	Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
Protein Name	Mast/Stem Cell Growth Factor Receptor Kit Scfr Piebald Trait Protein Pbt Proto-Oncogene C-Kit Tyrosine-Protein Kinase Kit P145 C-Kit V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog Cd Antigen Cd117
Database Links	Reactome: R-HSA-1257604 Reactome: R-HSA-1433557 Reactome: R-HSA-1433559 Reactome: R-HSA-2219530 Reactome: R-HSA-5673001 Reactome: R-HSA-6811558 Reactome: R-HSA-8866910 Reactome: R-HSA-9669914 Reactome: R-HSA-9669917 Reactome: R-HSA-9669921 Reactome: R-HSA-9669924 Reactome: R-HSA-9669926 Reactome: R-HSA-9669929 Reactome: R-HSA-9669933 Reactome: R-HSA-9669934 Reactome: R-HSA-9669935 Reactome: R-HSA-9669936 Reactome: R-HSA-9670439 Reactome: R-HSA-9680187
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Cell Membrane Isoform 3: Cytoplasm Detected In The Cytoplasm Of Spermatozoa Especially In The Equatorial And Subacrosomal Region Of The Sperm Head
Alternative Protein Names	Mast/Stem Cell Growth Factor Receptor Kit protein Scfr protein Piebald Trait Protein protein Pbt protein Proto-Oncogene C-Kit protein Tyrosine-Protein Kinase Kit protein P145 C-Kit protein V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog protein Cd Antigen Cd117 protein KIT protein SCFR protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

姓名：

電話：

您的需求：

產品名稱：Human c-Kit/CD117 protein (Recombinant) (C-hFc &amp; His) (STJP002568)

產品名稱：Human c-Kit/CD117 protein (Recombinant) (C-hFc & His) (STJP002568)