Human Cathepsin D protein (Recombinant) (C-His) (STJP000985) STJP000985|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Human Cathepsin D protein (Recombinant) (C-His) (STJP000985)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human Cathepsin D-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity:	Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2. The specific activity is >747 pmol/min/Mu g.

Gene Symbol:	CTSD
Gene ID:	1509
Uniprot ID:	CATD_HUMAN
Immunogen Region:	Leu21-Leu412
Immunogen:	Recombinant Human Cathepsin D Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu21-Leu412) of human Cathepsin D/CTSD (Accession #NP_001900.1) fused with a 6×His tag at the C-terminus.

Tissue Specificity	Expressed in the aorta extracellular space (at protein level). Expressed in liver (at protein level).
Post Translational Modifications	N- and O-glycosylated. Undergoes proteolytic cleavage and activation by ADAM30. As well as the major heavy chain which starts at Leu-169, 2 minor forms starting at Gly-170 and Gly-171 have been identified. An additional form starting at Ala-168 has also been identified.
Function	Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Protein Name	Cathepsin D Cleaved Into - Cathepsin D Light Chain - Cathepsin D Heavy Chain
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-2022377 Reactome: R-HSA-2132295 Reactome: R-HSA-6798695 Reactome: R-HSA-77387 Reactome: R-HSA-9018519
Cellular Localisation	Lysosome Melanosome Secreted Extracellular Space Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv In Aortic Samples Detected As An Extracellular Protein Loosely Bound To The Matrix
Alternative Protein Names	Cathepsin D Cleaved Into - Cathepsin D Light Chain - Cathepsin D Heavy Chain protein CTSD protein CPSD protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Human Cathepsin D protein (Recombinant) (C-His) (STJP000985)