Alpha Synuclein Blocking Peptide peptide (STJ504398) STJ504398-250|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Alpha Synuclein Blocking Peptide peptide (STJ504398)
產品型號：STJ504398-250
產品廠商：ST john's laboratory
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Alpha Synuclein Blocking Peptide peptide (STJ504398)

詳情介紹：

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Alpha Synuclein Blocking Peptide is synthetically produced from the 62-112 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	SNCA
Gene ID:	6622
Uniprot ID:	SYUA_HUMAN
Immunogen Region:	62-112
Immunogen:	Synthetic peptide taken within amino acid region 62-112 unique sequence on alpha-synuclein isoform NACP 112 protein.

Tissue Specificity	Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain.
Post Translational Modifications	Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress. Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers. Ubiquitinated. The predominant conjugate is the diubiquitinated form. Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
Function	Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
Peptide Name	Alpha-Synuclein Non-A Beta Component Of Ad Amyloid Non-A4 Component Of Amyloid Precursor Nacp
Database Links	Reactome: R-HSA-977225
Cellular Localisation	Cytoplasm Membrane Nucleus Synapse Secreted Cell Projection Axon Membrane-Bound In Dopaminergic Neurons Expressed And Colocalized With Septin4 In Dopaminergic Axon Terminals Especially At The Varicosities
Alternative Peptide Names	Alpha-Synuclein protein Non-A Beta Component Of Ad Amyloid protein Non-A4 Component Of Amyloid Precursor protein Nacp protein SNCA protein NACP protein PARK1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Alpha Synuclein Blocking Peptide peptide (STJ504398)