Anti-ABCA12 antibody (2456-2595) (STJ11103881) STJ11103881|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-ABCA12 antibody (2456-2595) (STJ11103881)
產品型號：STJ11103881
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-ABCA12 antibody (2456-2595) (STJ11103881)

詳情介紹：

Host:	Rabbit
Applications:	IF
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Glucosylceramide Transporter Abca12 (2456-2595) is suitable for use in Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABCA12
Gene ID:	26154
Uniprot ID:	ABCAC_HUMAN
Immunogen Region:	2456-2595
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 2456-2595 of human ABCA12 (NP_775099.2).
Immunogen Sequence:	CTRLAIMVNGKFQCIGSLQH IKSRFGRGFTVKVHLKNNKV TMETLTKFMQLHFPKTYLKD QHLSMLEYHVPVTAGGVANI FDLLETNKTALNITNFLVSQ TTLEEVFINFAKDQKSYETA DTSSQGSTISVDSQDDQMES

Tissue Specificity	Mainly expressed in the stomach, placenta, testis and fetal brain. Expressed in the upper epidermal layers, mainly the granular layers, of skin. Expressed throughout the normal interfollicular epidermis with prominent expression in the stratum granulosum. Expressed in alpha and beta cells of pancreatic islets.
Function	Transports lipids such as glucosylceramides from the outer to the inner leaflet of lamellar granules (LGs) membrane, whereby the lipids are finally transported to the keratinocyte periphery via the trans-Golgi network and LGs and released to the apical surface of the granular keratinocytes to form lipid lamellae in the stratum corneum of the epidermis, which is essential for skin barrier function. In the meantime, participates in the transport of the lamellar granules-associated proteolytic enzymes, in turn regulates desquamation and keratinocyte differentiation. Furthermore, is essential for the regulation of cellular cholesterol homeostasis by regulating ABCA1-dependent cholesterol efflux from macrophages through interaction with NR1H2 and ABCA1. Plays pleiotropic roles in regulating glucose stimulated insulin secretion from beta cells, regulating the morphology and fusion of insulin granules, lipid raft abundance and the actin cytoskeleton. Also involved in lung surfactant biogenesis.
Protein Name	Glucosylceramide Transporter Abca12 Atp-Binding Cassette Sub-Family A Member 12 Atp-Binding Cassette Transporter 12 Atp-Binding Cassette 12
Database Links	Reactome: R-HSA-1369062 Reactome: R-HSA-5682294
Cellular Localisation	Cytoplasmic Vesicle Secretory Vesicle Membrane Multi-Pass Membrane Protein Golgi Apparatus Membrane Localizes In The Limiting Membrane Of The Lamellar Granules (Lgs) Trafficks From The Golgi Apparatus To The Lamellar Granules (Lgs) At The Cell Periphery In The Uppermost Granular Layer Keratinocytes Where Abca12-Positive Lgs Fuse With The Keratinocyte-Cell Membrane To Secrete Their Lipid Content To The Extracellular Space Of The Stratum Corneum Co-Localizes Through The Golgi Apparatus To The Cell Periphery With Glucosylceramide
Alternative Antibody Names	Anti-Glucosylceramide Transporter Abca12 antibody Anti-Atp-Binding Cassette Sub-Family A Member 12 antibody Anti-Atp-Binding Cassette Transporter 12 antibody Anti-Atp-Binding Cassette 12 antibody Anti-ABCA12 antibody Anti-ABC12 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ABCA12 antibody (2456-2595) (STJ11103881)