产品详情

  • 产品名称：ASXL1 Blocking Peptide for STJ506146 peptide (STJ505857)

  • 产品型号：STJ505857-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
ASXL1 Blocking Peptide for STJ506146 peptide (STJ505857)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: ASXL1 Blocking Peptide for STJ506146 is synthetically produced from the 1120-1180 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Asxl1
Gene ID: 228790
Uniprot ID: ASXL1_MOUSE
Immunogen Region: 1120-1180
Specificity: This blocking peptide is recommended for use in combination with ASXL1 antibody, STJ506146
Immunogen: Synthetic peptide taken within amino acid region 1120-1180 on mouse Putative Polycomb group protein ASXL1.
Post Translational Modifications Ubiquitinated by TRIP12, leading to its subsequent degradation following binding N(6)-methyladenosine methylated DNA (m6A).
Function Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator of RARA and RXRA through association with NCOA1. Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing.
Peptide Name Polycomb Group Protein Asxl1
Additional Sex Combs-Like Protein 1
Database Links Reactome: R-MMU-5689603
Cellular Localisation Nucleus
Alternative Peptide Names Polycomb Group Protein Asxl1 protein
Additional Sex Combs-Like Protein 1 protein
Asxl1 protein
Kiaa0978 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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