产品详情

  • 产品名称：Anti-ABCE1/RNAse L inhibitor antibody (C-Term) (STJ70756)

  • 产品型号：STJ70756-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ABCE1/RNAse L inhibitor antibody (C-Term) (STJ70756)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Dog/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-ABCE1/RNAse L inhibitor (C-Term) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.3-1µg/ml
ELISA-antibody detection limit dilution 1:8000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ABCE1
Gene ID: 6059
Uniprot ID: ABCE1_HUMAN
Immunogen Region: C-Term
Accession Number: NP_002931.2; NP_001035809.1
Specificity: Variants (NP_002931.2; NP_001035809.1) encode the same protein.
Immunogen Sequence: KLNSIKDVEQKK
Function Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly. Able to hydrolyze ATP, GTP, UTP and CTP. Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits. Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage.this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL. Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway. (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections.
Protein Name Atp-Binding Cassette Sub-Family E Member 1
2'-5'-Oligoadenylate-Binding Protein
Huhp68
Rnase L Inhibitor
Ribonuclease 4 Inhibitor
Rns4i
Database Links Reactome: R-HSA-8983711
Reactome: R-HSA-909733
Cellular Localisation Cytoplasm
Mitochondrion
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family E Member 1 antibody
Anti-2'-5'-Oligoadenylate-Binding Protein antibody
Anti-Huhp68 antibody
Anti-Rnase L Inhibitor antibody
Anti-Ribonuclease 4 Inhibitor antibody
Anti-Rns4i antibody
Anti-ABCE1 antibody
Anti-RLI antibody
Anti-RNASEL1 antibody
Anti-RNASELI antibody
Anti-RNS4I antibody
Anti-OK antibody
Anti-SW-cl.40 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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