产品详情

  • 产品名称：Human S100-A12 protein (Active Recombinant) (C-His) (STJP000783)

  • 产品型号：STJP000783
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human S100-A12 protein (Active Recombinant) (C-His) (STJP000783)
详情介绍：
Host: E. coli
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Active Recombinant-Human S100-A12-C-His protein was developed from e. coli and has a target region of C-His. For use in research applications.
Formulation: Supplied in PBS, 25% Glycerol, pH 7.4Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human S100A12 at 2 Mu g/mL (100 Mu L/well) can bind recombinant Human AGER/RAGE with a linear range of 0.1-27.25 ng/mL.
Gene Symbol: S100A12
Gene ID: 6283
Uniprot ID: S10AC_HUMAN
Immunogen Region: Met1-Glu92
Immunogen: Recombinant Human S100-A12 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Glu92) of human S100A12 (Accession #NP_005612.1) fused with a 6×His tag at the C-terminus.
Tissue Specificity Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease.
Function S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases.MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.
Protein Name Protein S100-A12
Cgrp
Calcium-Binding Protein In Amniotic Fluid 1
Caaf1
Calgranulin-C
Cagc
Extracellular Newly Identified Rage-Binding Protein
En-Rage
Migration Inhibitory Factor-Related Protein 6
Mrp-6
P6
Neutrophil S100 Protein
S100 Calcium-Binding Protein A12 Cleaved Into - Calcitermin
Database Links Reactome: R-HSA-445989
Reactome: R-HSA-6798695
Reactome: R-HSA-879415
Reactome: R-HSA-933542
Cellular Localisation Secreted
Cytoplasm
Cytoskeleton
Cell Membrane
Peripheral Membrane Protein
Predominantly Localized In The Cytoplasm
Upon Elevation Of The Intracellular Calcium Level
Translocated From The Cytoplasm To The Cytoskeleton And The Cell Membrane
Upon Neutrophil Activation Is Secreted Via A Microtubule-Mediated
Alternative Pathway
Alternative Protein Names Protein S100-A12 protein
Cgrp protein
Calcium-Binding Protein In Amniotic Fluid 1 protein
Caaf1 protein
Calgranulin-C protein
Cagc protein
Extracellular Newly Identified Rage-Binding Protein protein
En-Rage protein
Migration Inhibitory Factor-Related Protein 6 protein
Mrp-6 protein
P6 protein
Neutrophil S100 Protein protein
S100 Calcium-Binding Protein A12 Cleaved Into - Calcitermin protein
S100A12 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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