产品详情

  • 产品名称：Anti-ATP6AP1 antibody (90-390) (STJ22724)

  • 产品型号：STJ22724
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ATP6AP1 antibody (90-390) (STJ22724)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ATP6AP1 (90-390) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:100-1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ATP6AP1
Gene ID: 537
Uniprot ID: VAS1_HUMAN
Immunogen Region: 90-390
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 90-390 of human ATP6AP1 (NP_001174.2).
Immunogen Sequence: LLFLQDKLSIEDFTAYGGVF GNKQDSAFSNLENALDLAPS SLVLPAVDWYAVSTLTTYLQ EKLGASPLHVDLATLRELKL NASLPALLLIRLPYTASSGL MAPREVLTGNDEVIGQVLST LKSEDVPYTAALTAVRPSRV ARDVAVVAGGLGRQLLQKQP VSPVIHPPVSYNDTAPRILF WAQNFSVAYKDQWEDLTPLT FGVQELNLTGSFWNDSFARL SLTYERLFGTTVTFKFILA
Tissue Specificity widely expressed, with highest levels in brain and lowest in liver and duodenum.
Post Translational Modifications N-glycosylated.
Function Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex (Probable). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules.
Protein Name V-Type Proton Atpase Subunit S1
V-Atpase Subunit S1
Protein Xap-3
V-Atpase Ac45 Subunit
V-Atpase S1 Accessory Protein
Vacuolar Proton Pump Subunit S1
Database Links Reactome: R-HSA-77387
Reactome: R-HSA-8980692
Reactome: R-HSA-917977
Reactome: R-HSA-983712
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Clathrin-Coated Vesicle Membrane
Not Detected In Trans-Golgi Network
Alternative Antibody Names Anti-V-Type Proton Atpase Subunit S1 antibody
Anti-V-Atpase Subunit S1 antibody
Anti-Protein Xap-3 antibody
Anti-V-Atpase Ac45 Subunit antibody
Anti-V-Atpase S1 Accessory Protein antibody
Anti-Vacuolar Proton Pump Subunit S1 antibody
Anti-ATP6AP1 antibody
Anti-ATP6IP1 antibody
Anti-ATP6S1 antibody
Anti-VATPS1 antibody
Anti-XAP3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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