产品详情

  • 产品名称：Anti-CAMKK2 antibody (1-100) (STJ111941)

  • 产品型号：STJ111941
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CAMKK2 antibody (1-100) (STJ111941)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CAMKK2 (1-100) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:100-1:500
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CAMKK2
Gene ID: 10645
Uniprot ID: KKCC2_HUMAN
Immunogen Region: 1-100
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human CAMKK2 (NP_006540.3).
Immunogen Sequence: MSSCVSSQPSSNRAAPQDEL GGRGSSSSESQKPCEALRGL SSLSIHLGMESFIVVTECEP GCAVDLGLARDRPLEADGQE VPLDTSGSQARPHLSGRKLS
Tissue Specificity Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.
Post Translational Modifications Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.
Function Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. Seems to be involved in hippocampal activation of CREB1. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Protein Name Calcium/Calmodulin-Dependent Protein Kinase Kinase 2
Cam-Kk 2
Cam-Kinase Kinase 2
Camkk 2
Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta
Cam-Kk Beta
Cam-Kinase Kinase Beta
Camkk Beta
Database Links Reactome: R-HSA-111932
Reactome: R-HSA-442729
Reactome: R-HSA-9619229
Reactome: R-HSA-9619483
Cellular Localisation Nucleus
Cytoplasm
Cell Projection
Neuron Projection
Predominantly Nuclear In Unstimulated Cells
Relocalizes Into Cytoplasm And Neurites After Forskolin Induction
Alternative Antibody Names Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 antibody
Anti-Cam-Kk 2 antibody
Anti-Cam-Kinase Kinase 2 antibody
Anti-Camkk 2 antibody
Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta antibody
Anti-Cam-Kk Beta antibody
Anti-Cam-Kinase Kinase Beta antibody
Anti-Camkk Beta antibody
Anti-CAMKK2 antibody
Anti-CAMKKB antibody
Anti-KIAA0787 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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