Anti-FBXO5 antibody (1-250) (STJ11100403) STJ11100403|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-FBXO5 antibody (1-250) (STJ11100403)
產品型號：STJ11100403
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-FBXO5 antibody (1-250) (STJ11100403)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FBXO5 (1-250) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FBXO5
Gene ID:	26271
Uniprot ID:	FBX5_HUMAN
Immunogen Region:	1-250
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human FBXO5 (NP_036309.1).
Immunogen Sequence:	MSRRPCSCALRPPRCSCSAS PSAVTAAGRPRPSDSCKEES STLSVKMKCDFNCNHVHSGL KLVKPDDIGRLVSYTPAYLE GSCKDCIKDYERLSCIGSPI VSPRIVQLETESKRLHNKEN QHVQQTLNSTNEIEALETSR LYEDSGYSSFSLQSGLSEHE EGSLLEENFGDSLQSCLLQI QSPDQYPNKNLLPVLHFEKV VCSTLKKNAKRNPKVDREML KEIIARGNFRLQNIIGRKM

Post Translational Modifications	Phosphorylation by CDK2 and subsequently by PLK1 triggers degradation during early mitosis through ubiquitin-mediated proteolysis by the SCF ubiquitin ligase complex containing the F-box protein BTRC. This degradation is necessary for the activation of APC in late mitosis and subsequent mitotic progression. Phosphorylated by RPS6KA2.increases and stabilizes interaction with CDC20. Ubiquitinated by the SCF(BTRC) complex following phosphorylation by PLK1. Undergoes both 'Lys-11' and 'Lys-48'-linked polyubiquitination by APC-FZR1 complex leading to degradation by proteasome during G1 phase. Degraded through the SCF(BTRC) complex.degradation occurs during oocyte maturation, between germinal vesicle breakdown (GVBD) and meiosesis I, and is required for the meiosesis I-meiosesis II transition.
Function	Regulator of APC activity during mitotic and meiotic cell cycle. During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex. During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase. Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment. As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10.by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities. Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence. During oocyte maturation, plays a role in meiosesis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization. Controls entry into the first meiotic division through inactivation of APC-FZR1 complex. Promotes migration and osteogenic differentiation of mesenchymal stem cells.
Protein Name	F-Box Only Protein 5 Early Mitotic Inhibitor 1
Database Links	Reactome: R-HSA-174113 Reactome: R-HSA-176408 Reactome: R-HSA-176417 Reactome: R-HSA-68881 Reactome: R-HSA-69205
Cellular Localisation	Nucleus Cytoplasm Cytoskeleton Spindle In Interphase Localizes In A Punctate Manner In The Nucleus And Cytoplasm With Some Perinuclear Concentration In Mitotic Cells Localizes Throughout The Cell Particularly At The Spindle
Alternative Antibody Names	Anti-F-Box Only Protein 5 antibody Anti-Early Mitotic Inhibitor 1 antibody Anti-FBXO5 antibody Anti-EMI1 antibody Anti-FBX5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FBXO5 antibody (1-250) (STJ11100403)