Anti-FBXO6 antibody (70-260) (STJ118010) STJ118010|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Anti-FBXO6 antibody (70-260) (STJ118010)

詳情介紹：

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FBXO6 (70-260) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FBXO6
Gene ID:	26270
Uniprot ID:	FBX6_HUMAN
Immunogen Region:	70-260
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 70-260 of human FBXO6 (NP_060908.1).
Immunogen Sequence:	QPVADWKIFYFLRSLHRNLL RNPCAEEDMFAWQIDFNGGD RWKVESLPGAHGTDFPDPKV KKYFVTSYEMCLKSQLVDLV AEGYWEELLDTFRPDIVVKD WFAARADCGCTYQLKVQLAS ADYFVLASFEPPPVTIQQWN NATWTEVSYTFSDYPRGVRY ILFQHGGRDTQYWAGWYGPR VTNSSIVVSPK

Function	Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
Protein Name	F-Box Only Protein 6 F-Box Protein That Recognizes Sugar Chains 2 F-Box/G-Domain Protein 2
Database Links	Reactome: R-HSA-390471 Reactome: R-HSA-8951664 Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm
Alternative Antibody Names	Anti-F-Box Only Protein 6 antibody Anti-F-Box Protein That Recognizes Sugar Chains 2 antibody Anti-F-Box/G-Domain Protein 2 antibody Anti-FBXO6 antibody Anti-FBG2 antibody Anti-FBS2 antibody Anti-FBX6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FBXO6 antibody (70-260) (STJ118010)