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Anti-CREB1 antibody (1-341) (STJ113894) STJ113894|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司
產品詳情

  • 產品名稱：Anti-CREB1 antibody (1-341) (STJ113894)

  • 產品型號：STJ113894
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-CREB1 antibody (1-341) (STJ113894)
詳情介紹：
Host: Rabbit
Applications: WB/IHC/IF/IP
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CREB1 (1-341) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and Immunoprecipitation research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
IP 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CREB1
Gene ID: 1385
Uniprot ID: CREB1_HUMAN
Immunogen Region: 1-341
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-341 of human CREB1 (NP_604391.1).
Immunogen Sequence: MTMESGAENQQSGDAAVTEA ENQQMTVQAQPQIATLAQVS MPAAHATSSAPTVTLVQLPN GQTVQVHGVIQAAQPSVIQS PQVQTVQSSCKDLKRLFSGT QISTIAESEDSQESVDSVTD SQKRREILSRRPSYRKILND LSSDAPGVPRIEEEKSEEET SAPAITTVTVPTPIYQTSSG QYIAITQGGAIQLANNGTDG VQGLQTLTMTNAAATQPGTT ILQYAQTTDGQQILVPSNQ
Post Translational Modifications Stimulated by phosphorylation. Phosphorylation of both Ser-119 and Ser-128 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-119 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion. CREBL2 positively regulates phosphorylation at Ser-119 thereby stimulating CREB1 transcriptional activity. Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-119. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-128. Phosphorylation of Ser-128 blocks CREB-mediated transcription even when Ser-119 is phosphorylated. Phosphorylated by CaMK1. Phosphorylation of Ser-257 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-119 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. Phosphorylated by TSSK4 on Ser-119. Sumoylated with SUMO1. Sumoylation on Lys-290, but not on Lys-271, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.
Function Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling.
Protein Name Cyclic Amp-Responsive Element-Binding Protein 1
Creb-1
Camp-Responsive Element-Binding Protein 1
Database Links Reactome: R-HSA-111931
Reactome: R-HSA-111932
Reactome: R-HSA-198693
Reactome: R-HSA-199920
Reactome: R-HSA-2151201
Reactome: R-HSA-2197563
Reactome: R-HSA-375165
Reactome: R-HSA-400253
Reactome: R-HSA-442720
Reactome: R-HSA-442729
Reactome: R-HSA-442742
Reactome: R-HSA-5674400
Reactome: R-HSA-881907
Reactome: R-HSA-9022692
Reactome: R-HSA-9022699
Reactome: R-HSA-9022702
Reactome: R-HSA-9022707
Reactome: R-HSA-9031628
Reactome: R-HSA-9609690
Reactome: R-HSA-9616222
Reactome: R-HSA-9634638
Reactome: R-HSA-9660821
Reactome: R-HSA-9664323
Reactome: R-HSA-9707616
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Cyclic Amp-Responsive Element-Binding Protein 1 antibody
Anti-Creb-1 antibody
Anti-Camp-Responsive Element-Binding Protein 1 antibody
Anti-CREB1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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