產品詳情
簡單介紹:
Anti-CYP39A1 antibody (Internal) (STJ92592)
詳情介紹:
Host: | Rabbit |
Applications: | WB/IHC/IF/ELISA |
Reactivity: | Human/Rat/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-24-hydroxycholesterol 7-alpha-hydroxylase (Internal) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CYP39A1 |
Gene ID: | 51302 |
Uniprot ID: | CP39A_HUMAN |
Immunogen Region: | Internal |
Specificity: | CYP39A1 Polyclonal Antibody detects endogenous levels of CYP39A1 protein. |
Immunogen: | Synthesized peptide derived from the Internal region of human CYP39A1. |
Function | A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). |
Protein Name | 24-Hydroxycholesterol 7-Alpha-Hydroxylase Cytochrome P450 39a1 Hcyp39a1 Oxysterol 7-Alpha-Hydroxylase |
Database Links | Reactome: R-HSA-193775 Reactome: R-HSA-211976 |
Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Microsome Membrane |
Alternative Antibody Names | Anti-24-Hydroxycholesterol 7-Alpha-Hydroxylase antibody Anti-Cytochrome P450 39a1 antibody Anti-Hcyp39a1 antibody Anti-Oxysterol 7-Alpha-Hydroxylase antibody Anti-CYP39A1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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