Anti-Cytokeratin 18 antibody (250-430) [S8MR] (STJ11103128) STJ11103128|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Anti-Cytokeratin 18 antibody (250-430) [S8MR] (STJ11103128)

詳情介紹：

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Cytokeratin 18 (KRT18) (250-430) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	S8MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:500-1:1000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	KRT18
Gene ID:	3875
Uniprot ID:	K1C18_HUMAN
Immunogen Region:	250-430
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 250-430 of human Cytokeratin 18 (KRT18) (P05783).
Immunogen Sequence:	ADIRAQYDELARKNREELDK YWSQQIEESTTVVTTQSAEV GAAETTLTELRRTVQSLEID LDSMRNLKASLENSLREVEA RYALQMEQLNGILLHLESEL AQTRAEGQRQAQEYEALLNI KVKLEAEIATYRRLLEDGED FNLGDALDSSNSMQTIQKTT TRRIVDGKVVSETNDTKVLR H

Tissue Specificity	Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Post Translational Modifications	Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7. O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.
Function	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Protein Name	Keratin - Type I Cytoskeletal 18 Cell Proliferation-Inducing Gene 46 Protein Cytokeratin-18 Ck-18 Keratin-18 K18
Database Links	Reactome: R-HSA-6805567 Reactome: R-HSA-6809371
Cellular Localisation	Nucleus Matrix Cytoplasm Perinuclear Region Nucleus Nucleolus
Alternative Antibody Names	Anti-Keratin - Type I Cytoskeletal 18 antibody Anti-Cell Proliferation-Inducing Gene 46 Protein antibody Anti-Cytokeratin-18 antibody Anti-Ck-18 antibody Anti-Keratin-18 antibody Anti-K18 antibody Anti-KRT18 antibody Anti-CYK18 antibody Anti-PIG46 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-Cytokeratin 18 antibody (250-430) [S8MR] (STJ11103128)