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Anti-DBN1 antibody (350-649) (STJ28449) STJ28449|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司
產品詳情

  • 產品名稱：Anti-DBN1 antibody (350-649) (STJ28449)

  • 產品型號：STJ28449
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-DBN1 antibody (350-649) (STJ28449)
詳情介紹：
Host: Rabbit
Applications: WB/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DBN1 (350-649) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DBN1
Gene ID: 1627
Uniprot ID: DREB_HUMAN
Immunogen Region: 350-649
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 350-649 of human DBN1 (NP_004386.2).
Immunogen Sequence: EQIERALDEVTSSQPPPLPP PPPPAQETQEPSPILDSEET RAAAPQAWAGPMEEPPQAQA PPRGPGSPAEDLMFMESAEQ AVLAAPVEPATADATEIHDA ADTIETDTATADTTVANNVP PAATSLIDLWPGNGEGASTL QGEPRAPTPPSGTEVTLAEV PLLDEVAPEPLLPAGEGCAT LLNFDELPEPPATFCDPEEV EGEPLAAPQTPTLPSALEEL EQEQEPEPHLLTNGETTQK
Tissue Specificity Expressed in the brain, with expression in the molecular layer of the dentate gyrus, stratum pyramidale, and stratum radiatum of the hippocampus (at protein level). Also expressed in the terminal varicosities distributed along dendritic trees of pyramidal cells in CA4 and CA3 of the hippocampus (at protein level). Expressed in pyramidal cells in CA2, CA1 and the subiculum of the hippocampus (at protein level). Expressed in peripheral blood lymphocytes, including T-cells (at protein level). Expressed in the brain. Expressed in the heart, placenta, lung, skeletal muscle, kidney, pancreas, skin fibroblasts, gingival fibroblasts and bone-derived cells (Ref.2).
Function Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus.
Protein Name Drebrin
Developmentally-Regulated Brain Protein
Database Links Reactome: R-HSA-9013405
Reactome: R-HSA-9013407
Reactome: R-HSA-9013418
Reactome: R-HSA-9013422
Cellular Localisation Cytoplasm
Cell Projection
Dendrite
Cell Cortex
Cell Junction
Growth Cone
In The Absence Of Antigen
Evenly Distributed Throughout Subcortical Regions Of The T-Cell Membrane And Cytoplasm
In The Presence Of Antigen
Distributes To The Immunological Synapse Forming At The T-Cell-Apc Contact Area
Where It Localizes At The Peripheral And Distal Supramolecular Activation Clusters (Smac)
Colocalized With Rufy3 And F-Actin At The Transitional Domain Of The Axonal Growth Cone
Alternative Antibody Names Anti-Drebrin antibody
Anti-Developmentally-Regulated Brain Protein antibody
Anti-DBN1 antibody
Anti-D0S117E antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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