產品詳情
簡單介紹：
Anti-CD276 antibody (29-245) (STJ119347)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-B7-H3/CD276 (29-245) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD276 |
| Gene ID: | 80381 |
| Uniprot ID: | CD276_HUMAN |
| Immunogen Region: | 29-245 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 29-245 of human CD276/B7-H3 (NP_079516.1). |
| Immunogen Sequence: | LEVQVPEDPVVALVGTDATL CCSFSPEPGFSLAQLNLIWQ LTDTKQLVHSFAEGQDQGSA YANRTALFPDLLAQGNASLR LQRVRVADEGSFTCFVSIRD FGSAAVSLQVAAPYSKPSMT LEPNKDLRPGDTVTITCSSY RGYPEAEVFWQDGQGVPLTG NVTTSQMANEQGLFDVHSVL RVVLGANGTYSCLVRNPVLQ QDAHGSVTITGQPMTFP |
| Tissue Specificity | Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. |
| Function | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. |
| Protein Name | Cd276 Antigen 4ig-B7-H3 B7 Homolog 3 B7-H3 Costimulatory Molecule Cd Antigen Cd276 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cd276 Antigen antibody Anti-4ig-B7-H3 antibody Anti-B7 Homolog 3 antibody Anti-B7-H3 antibody Anti-Costimulatory Molecule antibody Anti-Cd Antigen Cd276 antibody Anti-CD276 antibody Anti-B7H3 antibody Anti-PSEC0249 antibody Anti-UNQ309 antibody Anti-PRO352 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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