Mouse FAPa (Fibroblast Activation Protein Alpha) Sandwich ELISA Kit (STJE0008784) STJE0008784|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Mouse FAPa (Fibroblast Activation Protein Alpha) Sandwich ELISA Kit (STJE0008784)
產品型號：STJE0008784
產品廠商：ST john's laboratory
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Mouse FAPa (Fibroblast Activation Protein Alpha) Sandwich ELISA Kit (STJE0008784)

詳情介紹：

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	13.5pg/mL
Detection Limit:	31.2-2000pg/mL
Short Description:	This FAPa Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Fap
Gene ID:	14089
Uniprot ID:	SEPR_MOUSE
Sample Type:	serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expressed strongly in uterus, pancreas, submaxillary gland and skin, less in lymph node, ovary, skeletal muscle, adrenal and bone marrow. Expressed in reactive stromal fibroblast in epithelial cancers. Expressed in melanocytes but not melanomas (at protein level). Detected in fibroblasts, in placenta, uterus, embryos from day 7-19 and in newborn mice (P1).
Post Translational Modifications	N-glycosylated. The N-terminus may be blocked.
Function	Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2. Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein. Also has dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.
Protein Name	Prolyl Endopeptidase Fap Dipeptidyl Peptidase Fap Fibroblast Activation Protein Alpha Fapalpha Gelatine Degradation Protease Fap Integral Membrane Serine Protease Post-Proline Cleaving Enzyme Serine Integral Membrane Protease Simp Surface-Expressed Protease Seprase Cleaved Into - Antiplasmin-Cleaving Enzyme Fap - Soluble Form Apce
Database Links
Cellular Localisation	Prolyl Endopeptidase Fap: Cell Surface Cell Membrane Single-Pass Type Ii Membrane Protein Cell Projection Lamellipodsium Membrane Invadopodium Membrane Ruffle Membrane Membrane Localized On Cell Surface With Lamellipodsia And Invadopodia Membranes And On Shed Vesicles Colocalized With Dpp4 At Invadopodia And Lamellipodsia Membranes Of Migratory Activated Endothelial Cells In Collagenous Matrix Colocalized With Dpp4 On Endothelial Cells Of Capillary-Like Microvessels But Not Large Vessels Within Invasive Breast Ductal Carcinoma Anchored And Enriched Preferentially By Integrin Alpha-3/Beta-1 At Invadopodia Plasma Membrane Protrusions That Correspond To Sites Of Cell Invasion In A Collagen-Dependent Manner Localized At Plasma And Ruffle Membranes In A Collagen-Independent Manner Colocalized With Plaur Preferentially At The Cell Surface Of Invadopodia Membranes In A Cytoskeleton- Integrin- And Vitronectin-Dependent Manner Concentrated At Invadopodia Membranes Specialized Protrusions Of The Ventral Plasma Membrane In A Fibrobectin-Dependent Manner Colocalizes With Extracellular Components (Ecm) Such As Collagen Fibers And Fibronectin Antiplasmin-Cleaving Enzyme Fap Soluble Form: Secreted Found In Blood Plasma And Serum
Alternative ELISA Names	Prolyl Endopeptidase Fap ELISA kit Dipeptidyl Peptidase Fap ELISA kit Fibroblast Activation Protein Alpha ELISA kit Fapalpha ELISA kit Gelatine Degradation Protease Fap ELISA kit Integral Membrane Serine Protease ELISA kit Post-Proline Cleaving Enzyme ELISA kit Serine Integral Membrane Protease ELISA kit Simp ELISA kit Surface-Expressed Protease ELISA kit Seprase Cleaved Into - Antiplasmin-Cleaving Enzyme Fap - Soluble Form ELISA kit Apce ELISA kit Fap ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Mouse FAPa (Fibroblast Activation Protein Alpha) Sandwich ELISA Kit (STJE0008784)