Anti-DDR1 antibody (602-681 aa) [2G4E12] (STJ97996) STJ97996|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-DDR1 antibody (602-681 aa) [2G4E12] (STJ97996)
產品型號：STJ97996
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-DDR1 antibody (602-681 aa) [2G4E12] (STJ97996)

詳情介紹：

Host:	Mouse
Applications:	WB/ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Epithelial discoidin domain-containing receptor 1 (602-681 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Monoclonal
Clone ID:	2G4E12
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 ELISA 1:10000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DDR1
Gene ID:	780
Uniprot ID:	DDR1_HUMAN
Immunogen Region:	602-681 aa
Specificity:	DDR1 Monoclonal Antibody detects endogenous levels of DDR1 protein.
Immunogen:	Purified recombinant fragment of DDR1 (aa602-681) expressed in E. Coli.

Post Translational Modifications	Autophosphorylated in response to fibrillar collagen binding. Glycosylation of Asn-211, but apparently not of Asn-260 or Asn-394, prevents autophosphorylation from occurring in the absence of collagen.
Function	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Protein Name	Epithelial Discoidin Domain-Containing Receptor 1 Epithelial Discoidin Domain Receptor 1 Cd167 Antigen-Like Family Member A Cell Adhesion Kinase Discoidin Receptor Tyrosine Kinase Hgk2 Mammary Carcinoma Kinase 10 Mck-10 Protein-Tyrosine Kinase 3a Protein-Tyrosine Kinase Rtk-6 Trk E Tyrosine Kinase Ddr Tyrosine-Protein Kinase Cak Cd Antigen Cd167a
Database Links	Reactome: R-HSA-3000171
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Cell Membrane Isoform 3: Secreted Isoform 4: Cell Membrane
Alternative Antibody Names	Anti-Epithelial Discoidin Domain-Containing Receptor 1 antibody Anti-Epithelial Discoidin Domain Receptor 1 antibody Anti-Cd167 Antigen-Like Family Member A antibody Anti-Cell Adhesion Kinase antibody Anti-Discoidin Receptor Tyrosine Kinase antibody Anti-Hgk2 antibody Anti-Mammary Carcinoma Kinase 10 antibody Anti-Mck-10 antibody Anti-Protein-Tyrosine Kinase 3a antibody Anti-Protein-Tyrosine Kinase Rtk-6 antibody Anti-Trk E antibody Anti-Tyrosine Kinase Ddr antibody Anti-Tyrosine-Protein Kinase Cak antibody Anti-Cd Antigen Cd167a antibody Anti-DDR1 antibody Anti-CAK antibody Anti-EDDR1 antibody Anti-NEP antibody Anti-NTRK4 antibody Anti-PTK3A antibody Anti-RTK6 antibody Anti-TRKE antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-DDR1 antibody (602-681 aa) [2G4E12] (STJ97996)