Anti-DEFB4A/DEFB4B antibody (1-50 aa) (STJ196526) STJ196526|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Anti-DEFB4A/DEFB4B antibody (1-50 aa) (STJ196526)

詳情介紹：

Host:	Rabbit
Applications:	IHC/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Defensin beta 4A (1-50 aa) is suitable for use in Immunohistochemistry and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IHC-P 1:50-200 ELISA-Pep 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DEFB4A.DEFB4B
Gene ID:	100289462/1673
Uniprot ID:	DFB4A_HUMAN
Immunogen Region:	1-50 aa
Specificity:	This antibody detects endogenous levels of human Beta-defensin 4A
Immunogen:	Synthesized peptide derived from the human Beta-defensin 4A at the amino acid range 1-50

Function	Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria. Antimicrobial activity against P.aruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM. Also exhibits antimicrobial activity against the yeast C.albicans. Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell fragmentation and cell death. Acts as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells, such as immature dendritic cells and memory T cells.
Protein Name	Defensin Beta 4a Beta-Defensin 2 Bd-2 Hbd-2 Defensin - Beta 2 Skin-Antimicrobial Peptide 1 Sap1
Database Links	Reactome: R-HSA-1461957 Reactome: R-HSA-1461973
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Defensin Beta 4a antibody Anti-Beta-Defensin 2 antibody Anti-Bd-2 antibody Anti-Hbd-2 antibody Anti-Defensin - Beta 2 antibody Anti-Skin-Antimicrobial Peptide 1 antibody Anti-Sap1 antibody Anti-DEFB4A antibody Anti-DEFB102 antibody Anti-DEFB2 antibody Anti-DEFB4.DEFB4B antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-DEFB4A/DEFB4B antibody (1-50 aa) (STJ196526)